产品
编 号：F500770
分子式：C10H12ClNO4
分子量：245.66
分子式：C10H12ClNO4
分子量：245.66
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 886-74-8
产品详情
生物活性：
Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant. Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation. Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels. Antinociceptive effect.
体内研究：
Chlorphenesin carbamate (CPC; 50 mg/kg i.v.) inhibits the mono (MSR) and poly-synaptic reflex (PSR), the latter being more susceptible than the former to CPC depression. Chlorphenesin carbamate has an apparent depressant action on the spinal neuron, and it hyperpolarized both the ventral and dorsal roots of the isolated frog spinal cord. Chlorphenesin carbamate (CPC) has an antinociceptive action in adjuvant arthritic rats. Chlorphenesin carbamate (100-400 mg/kg, p.o.) has a dose-dependent antinociceptive effect in the behavioral study. Chlorphenesin carbamate (25-50 mg/kg, i.v.) depresses the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB) in the electrophysiological study. Chlorphenesin carbamate (50 mg/kg, i.v.) depresses the spontaneous firings of the VB nociceptive neurons.Animal Model:Male Wister rats weighing 200-300 g
Dosage:50 mg/kg
Administration:Intravenously administered
Result:Significantly inhibited PSR, with the maximum inhibition at 40 min after the drug administration.
Chlorphenesin carbamate is a centrally acting skeletal muscle relaxant. Chlorphenesin carbamate can be used for the research of pain and discomfort related to skeletal muscle trauma and inflammation. Chlorphenesin carbamate is a selective blocker of polysynaptic pathways at the spinal and supra-spinal levels. Antinociceptive effect.
体内研究：
Chlorphenesin carbamate (CPC; 50 mg/kg i.v.) inhibits the mono (MSR) and poly-synaptic reflex (PSR), the latter being more susceptible than the former to CPC depression. Chlorphenesin carbamate has an apparent depressant action on the spinal neuron, and it hyperpolarized both the ventral and dorsal roots of the isolated frog spinal cord. Chlorphenesin carbamate (CPC) has an antinociceptive action in adjuvant arthritic rats. Chlorphenesin carbamate (100-400 mg/kg, p.o.) has a dose-dependent antinociceptive effect in the behavioral study. Chlorphenesin carbamate (25-50 mg/kg, i.v.) depresses the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB) in the electrophysiological study. Chlorphenesin carbamate (50 mg/kg, i.v.) depresses the spontaneous firings of the VB nociceptive neurons.Animal Model:Male Wister rats weighing 200-300 g
Dosage:50 mg/kg
Administration:Intravenously administered
Result:Significantly inhibited PSR, with the maximum inhibition at 40 min after the drug administration.
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