产品
编 号：F498793
分子式：C15H19NO2S
分子量：277.38
分子式：C15H19NO2S
分子量：277.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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200mg
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结构图
CAS No: 885434-70-8
产品详情
生物活性：
HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 μM.
体外研究：
HJC0350 has an apparent IC50 value of 0.3 μM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 μM HJC0350 fully blocks the 007-AM induced decrease of FRET.
HJC0350 is a potent and specific EPAC2 antagonist with an IC50 of 0.3 μM.
体外研究：
HJC0350 has an apparent IC50 value of 0.3 μM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 μM HJC0350 fully blocks the 007-AM induced decrease of FRET.
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