产品
编 号：F497082
分子式：CH10Cl2Na2O10P2
分子量：360.92
分子式：CH10Cl2Na2O10P2
分子量：360.92
产品类型
规格
价格
是否有货
50mg
148
In-stock
100mg
240
In-stock
250mg
480
In-stock
结构图
CAS No: 88416-50-6
产品详情
生物活性：
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.
体内研究：
Clodronate disodium tetrahydrate (10 mg/kg；iv) 通过抑制 VNUT 减轻炎症性疼痛。Clodronate disodium tetrahydrate 通过抑制 VNUT 减轻炎症。Animal Model:C57BL/6 mice (22-30 g)
Dosage:10 mg/kg
Administration:Intravenous injection
Result:Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain.
体外研究：
Clodronate disodium tetrahydrate 是第一代双膦酸盐，通过抑制 VNUT 显著减轻与骨骼异常无关的神经性和炎症性疼痛，VNUT 是启动嘌呤能化学传递的关键分子。 Clodronate disodium tetrahydrate 在骨质疏松症中作为抗骨吸收药物。
Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain.
体内研究：
Clodronate disodium tetrahydrate (10 mg/kg；iv) 通过抑制 VNUT 减轻炎症性疼痛。Clodronate disodium tetrahydrate 通过抑制 VNUT 减轻炎症。Animal Model:C57BL/6 mice (22-30 g)
Dosage:10 mg/kg
Administration:Intravenous injection
Result:Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain.
体外研究：
Clodronate disodium tetrahydrate 是第一代双膦酸盐，通过抑制 VNUT 显著减轻与骨骼异常无关的神经性和炎症性疼痛，VNUT 是启动嘌呤能化学传递的关键分子。 Clodronate disodium tetrahydrate 在骨质疏松症中作为抗骨吸收药物。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备