产品
编 号：F496998
分子式：C22H25ClN2O3S
分子量：432.96
分子式：C22H25ClN2O3S
分子量：432.96
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 883976-12-3
产品详情
生物活性：
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb).
体内研究：
M8-B (6 mg/kg; i.v. or i.p.) 降低大鼠和小鼠的深部体温。Animal Model:Trpm8+/+ rats and mice
Dosage:6 mg/kg
Administration:I.v. or i.p.
Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.
体外研究：
M8-B (0-100 μM) 以剂量依赖性方式抑制最大 Ca2+ 摄取来抑制 TRPM8 通道活性。
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb).
体内研究：
M8-B (6 mg/kg; i.v. or i.p.) 降低大鼠和小鼠的深部体温。Animal Model:Trpm8+/+ rats and mice
Dosage:6 mg/kg
Administration:I.v. or i.p.
Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.
体外研究：
M8-B (0-100 μM) 以剂量依赖性方式抑制最大 Ca2+ 摄取来抑制 TRPM8 通道活性。
产品资料
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