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编 号：F496873
分子式：C30H39N5O7S2
分子量：645.79
分子式：C30H39N5O7S2
分子量：645.79
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CAS No: 88373-72-2
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生物活性：
[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin (HY-P0288).
体内研究：
[DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice.Animal Model:Male Sprague-Dawley rats (260-280 g)
Dosage:0, 1.16, 11.6 μg/kg
Administration:IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding.
Result:Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect.
Animal Model:Male Sprague-Dawley rats (260-280 g)
Dosage:0, 0.332, 3.32 μg/kg
Administration:IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment
Result:Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect.
[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin (HY-P0288).
体内研究：
[DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice.Animal Model:Male Sprague-Dawley rats (260-280 g)
Dosage:0, 1.16, 11.6 μg/kg
Administration:IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding.
Result:Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect.
Animal Model:Male Sprague-Dawley rats (260-280 g)
Dosage:0, 0.332, 3.32 μg/kg
Administration:IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment
Result:Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect.
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