产品
编 号：F496327
分子式：C26H28F3N3O2
分子量：471.51
分子式：C26H28F3N3O2
分子量：471.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 883031-03-6
产品详情
生物活性：
HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
体内研究：
HC-067047 (0-50 mg/kg; intraperitoneal injection; for 30 minutes; cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT mice) treatment increases functional bladder capacity and reduces micturition frequency in WT mice with cystitis. HC-067047 do not affect bladder function in Trpv4?/? mice.Animal Model:Cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT mice
Dosage:0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg
Administration:Intraperitoneal injection; for 30 minutes
Result:Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4?/? mice.
体外研究：
HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells.?HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.?HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation.?HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis.
HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
体内研究：
HC-067047 (0-50 mg/kg; intraperitoneal injection; for 30 minutes; cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT mice) treatment increases functional bladder capacity and reduces micturition frequency in WT mice with cystitis. HC-067047 do not affect bladder function in Trpv4?/? mice.Animal Model:Cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT mice
Dosage:0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg
Administration:Intraperitoneal injection; for 30 minutes
Result:Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4?/? mice.
体外研究：
HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells.?HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.?HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation.?HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis.
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