产品
编 号：F495818
分子式：C21H13FN2O2S
分子量：376.4
分子式：C21H13FN2O2S
分子量：376.4
产品类型
规格
价格
是否有货
1mg
833
In-stock
5mg
1920
In-stock
10mg
2970
In-stock
25mg
5055
In-stock
50mg
7320
In-stock
结构图
CAS No: 881970-80-5
产品详情
生物活性：
iMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice.
体内研究：
iMDK ((9 mg/kg/天；腹腔注射 100 ul) 和 PD0325901 (5 mg/kg；口服) 的联合处理有效地减少了异种移植小鼠模型中的肺肿瘤生长。Animal Model:female BALB/c nude mice (6 week old) bearing H441 human lung cancer xenografts
Dosage:iMDK (9 mg/kg) and PD0325901 (5 mg/kg)
Administration:Intraperitoneally injected with 100 μL iMDK everyday and/or orally administered PD0325901 five times per week (on days 1, 2, 3, 4, 5, 7, 8, 9, 10, 11)
Result:Reduced significantly volume of the tumors derived from H441 lung adenocarcinoma cells after the combination treatment with iMDK and PD0325901 compared to that of single compound in a xenograft mouse model.
体外研究：
处理 72 小时后，iMDK (50–500 nM) 以剂量依赖性方式抑制 H441 肺腺癌细胞中的 AKT 磷酸化。相比之下，iMDK 稳健地增加了 p-ERK。
iMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice.
体内研究：
iMDK ((9 mg/kg/天；腹腔注射 100 ul) 和 PD0325901 (5 mg/kg；口服) 的联合处理有效地减少了异种移植小鼠模型中的肺肿瘤生长。Animal Model:female BALB/c nude mice (6 week old) bearing H441 human lung cancer xenografts
Dosage:iMDK (9 mg/kg) and PD0325901 (5 mg/kg)
Administration:Intraperitoneally injected with 100 μL iMDK everyday and/or orally administered PD0325901 five times per week (on days 1, 2, 3, 4, 5, 7, 8, 9, 10, 11)
Result:Reduced significantly volume of the tumors derived from H441 lung adenocarcinoma cells after the combination treatment with iMDK and PD0325901 compared to that of single compound in a xenograft mouse model.
体外研究：
处理 72 小时后，iMDK (50–500 nM) 以剂量依赖性方式抑制 H441 肺腺癌细胞中的 AKT 磷酸化。相比之下，iMDK 稳健地增加了 p-ERK。
产品资料
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