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编 号：F495439
分子式：C26H42N6O12S2
分子量：694.77
分子式：C26H42N6O12S2
分子量：694.77
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CAS No: 881188-51-8
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生物活性：
Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.
体内研究：
Foxy-5 (2 mg/kg, 腹腔注射, 每天注射 9 次, 7-23 天) 在人结肠癌异种移植小鼠模型中减少结肠癌干细胞的数量。Foxy-5 (2 mg/kg, 腹腔注射, 每天 1 次, 3-9 周) 在前列腺癌异种移植小鼠模型中显著降低 WNT5A 低 DU145 前列腺癌细胞的早期转移扩散。Animal Model:A Xenograft Mouse Model of Human Colonic Cancer
Dosage:2 mg/kg
Administration:i.p. 9 times a day for 7-23 days
Result:Reduced the expression of ALDH, DCLK1 and COX-2.Increased the expression of 15-PGDH.Reduced the expression of the downstream β-catenin target ASCL2.
Animal Model:A Xenograft Mouse Model of Prostate Cancer
Dosage:2 mg/kg
Administration:i.p. once a day, for 3-9 weeks
Result:Reduced metastatic spread and the number of tumor cells in lymph nodes.
体外研究：
Foxy-5 (100 μM, 24 h) 在 DU145 细胞中可抑制肿瘤细胞的侵袭。
Foxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.
体内研究：
Foxy-5 (2 mg/kg, 腹腔注射, 每天注射 9 次, 7-23 天) 在人结肠癌异种移植小鼠模型中减少结肠癌干细胞的数量。Foxy-5 (2 mg/kg, 腹腔注射, 每天 1 次, 3-9 周) 在前列腺癌异种移植小鼠模型中显著降低 WNT5A 低 DU145 前列腺癌细胞的早期转移扩散。Animal Model:A Xenograft Mouse Model of Human Colonic Cancer
Dosage:2 mg/kg
Administration:i.p. 9 times a day for 7-23 days
Result:Reduced the expression of ALDH, DCLK1 and COX-2.Increased the expression of 15-PGDH.Reduced the expression of the downstream β-catenin target ASCL2.
Animal Model:A Xenograft Mouse Model of Prostate Cancer
Dosage:2 mg/kg
Administration:i.p. once a day, for 3-9 weeks
Result:Reduced metastatic spread and the number of tumor cells in lymph nodes.
体外研究：
Foxy-5 (100 μM, 24 h) 在 DU145 细胞中可抑制肿瘤细胞的侵袭。
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