产品
编 号：F495159
分子式：C38H44Cl2N4O6
分子量：723.69
分子式：C38H44Cl2N4O6
分子量：723.69
产品类型
规格
价格
是否有货
5mg
询价
询价
结构图
CAS No: 880759-65-9
产品详情
生物活性：
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity.
体内研究：
Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in miceAnimal Model:Male ICR mice, methamphetamine (METH)-induced locomotor activity model
Dosage:20 mg/kg
Administration:Intraperitoneal injection, once, 60 min before injecting saline (i.p.) or METH (1 mg/kg, i.p.)
Result:Significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels.
体外研究：
Naloxonazine is relatively stable in solution.Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM.Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection.Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth.
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity.
体内研究：
Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in miceAnimal Model:Male ICR mice, methamphetamine (METH)-induced locomotor activity model
Dosage:20 mg/kg
Administration:Intraperitoneal injection, once, 60 min before injecting saline (i.p.) or METH (1 mg/kg, i.p.)
Result:Significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels.
体外研究：
Naloxonazine is relatively stable in solution.Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM.Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection.Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth.
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