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编 号：F495139
分子式：C17H24N2O
分子量：272.39
分子式：C17H24N2O
分子量：272.39
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CAS No: 88069-67-4
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生物活性：
Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent.
体内研究：
Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current.Animal Model:Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment
Dosage:2 mg/kg
Administration:Bolus injection into right external carotid vein within 2 minutes, once
Result:Elongated the QT interval at 15 and 60 minutes after administration. Shortened P wave and QRS complex durations.Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
体外研究：
Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells.
Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent.
体内研究：
Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) decreases the conduction velocity in T4-treated rat atrium by decreasing the Max dV/dt and net inward current.Animal Model:Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment
Dosage:2 mg/kg
Administration:Bolus injection into right external carotid vein within 2 minutes, once
Result:Elongated the QT interval at 15 and 60 minutes after administration. Shortened P wave and QRS complex durations.Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
体外研究：
Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 μg/mL in levo-thyroxine (T4)-treated rat atrial cells.
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