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编 号:F494924
分子式:C19H18N2O2S
分子量:338.42
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.

体外研究:
Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects.Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker).Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2.Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells.Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner.
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