产品
编 号:F494158
分子式:C21H29ClN2O4S
分子量:440.98
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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生物活性:
JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system.

体内研究:
JNJ 303 recapitulates the Exn4-induced decrease in fasting blood glucose level in mice.

体外研究:
JNJ 303 can block IKs with an IC50 value of 64 nM. JNJ 303 (3.3 μM) does not have any effects on other cardiac channels.JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
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