产品
编 号：F493807
分子式：C16H19N3O2S
分子量：317.41
分子式：C16H19N3O2S
分子量：317.41
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 877963-94-5
产品详情
生物活性：
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding.LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells.
体内研究：
LOC14 (灌胃口服给药；20 mg/kg；每日一次；12-28 周) 显著改善 N171–82Q HD 小鼠的运动功能，减轻脑萎缩并延长生存期。Animal Model:Male N171–82Q HD mice
Dosage:20 mg/kg
Administration:Orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks
Result:Improved motor function in HD mice.
体外研究：
LOC14 (0.01-100 μM；24 小时) 表现出抑制重组 (r) PDIA3 的能力，IC50 约为 5 μM。
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding.LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells.
体内研究：
LOC14 (灌胃口服给药；20 mg/kg；每日一次；12-28 周) 显著改善 N171–82Q HD 小鼠的运动功能，减轻脑萎缩并延长生存期。Animal Model:Male N171–82Q HD mice
Dosage:20 mg/kg
Administration:Orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks
Result:Improved motor function in HD mice.
体外研究：
LOC14 (0.01-100 μM；24 小时) 表现出抑制重组 (r) PDIA3 的能力，IC50 约为 5 μM。
产品资料
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