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编 号：F493641
分子式：C27H26F3N3O2
分子量：481.51
分子式：C27H26F3N3O2
分子量：481.51
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CAS No: 877606-63-8
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生物活性：
Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB).
体内研究：
Afacifenacin (0.3, 1, 3 mg/kg; Intragastric administration) 显着增加脑梗死大鼠的膀胱容量和降低排尿压力 (MP)。Animal Model:Male Sprague-Dawley rats (cerebral infarction model)
Dosage:0.3, 1, 3 mg/kg
Administration:Intragastric administration
Result:Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).
Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB).
体内研究：
Afacifenacin (0.3, 1, 3 mg/kg; Intragastric administration) 显着增加脑梗死大鼠的膀胱容量和降低排尿压力 (MP)。Animal Model:Male Sprague-Dawley rats (cerebral infarction model)
Dosage:0.3, 1, 3 mg/kg
Administration:Intragastric administration
Result:Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).
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