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编 号:F493290
分子式:C15H10O5
分子量:270.24
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生物活性:
6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases.

体内研究:
6-hydroxyrubiadin can reduce the production of pro-inflammatory cytokines and ameliorate acute lung injury (ALI) in a mouse model.

体外研究:
6-hydroxyrubiadin suppresses lipopolysaccharide (LPS)-induced nuclear factor-kappa B activation as well as the phosphorylation of c-Jun N-terminal kinase in RAW 264.7 macrophages.6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-a, interleukin (IL)-1b and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7cells.
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