产品
编 号：F493264
分子式：C24H34N2O5
分子量：430.54
分子式：C24H34N2O5
分子量：430.54
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 87679-37-6
产品详情
生物活性：
Trandolapril (RU44570) is a nonsulfhydryl proagent that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI).
体内研究：
Trandolapril (3 mg/kg/day; p.o.; 7 d) reduces renal fibrosis in obstructive nephropathy in mice, by inhibiting renal interstitial matrix expression and myofibroblast activation, decreasing renal proinflammatory cytokine RANTES and TNF-α level.Trandolapril (0.3 mg/kg/day; p.o.; 4 weeks) improves arterial mechanics in rats, prevents arterial hypertrophy, collagen and cellular fibronectin accumulation.randolapril (0.3 mg/kg/day; p.o.; 4 months) exhibits a chronic anti-hypertension effects in rats, results in blood pressure decreasing.Trandolapril (0.25 mg/kg; p.o.; twice a day; 4 months) inhibits Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit.Animal Model:UUD (unilateral ureteral obstruction) model in Male CD-1 mice (18-22 g)
Dosage:3 mg/kg
Administration:Oral gavage; daily, for 7 days
Result:Resulted in renal interstitial matrix expression (including fibronectin, type I, and type III collagen) decreasing, and inhibited myofibroblast activation by surprising a-smooth muscle actin (a-SMA) expression, decreased the RANTES (regulated on activation, normal T cell expressed and secreted) and TNF-α level.
Animal Model:SHR model (spontaneously hypertensive rats, 4-week-old)
Dosage:0.3 mg/kg
Administration:Oral gavage; daily for 4 weeks
Result:Reduced collagen content in the aortic media and increased ariterial distensibility up to about 80%.
Animal Model:Watanabe heritable hyperlipidemic rabbit (3 months old)
Dosage:0.25 mg/kg
Administration:Oral gavage; twice a day; 9 months
Result:Decreased in atherosclerotic involvement of the intimal surface, and also decreased cholesterol content in descending thoracic aorta.
体外研究：
Trandolapril (0.02 mM, 1 mM; 3 d) inhibits cell growth and induces cell apoptosis, increases the percentage of apoptotic cells in K562 cell line.
Trandolapril (RU44570) is a nonsulfhydryl proagent that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI).
体内研究：
Trandolapril (3 mg/kg/day; p.o.; 7 d) reduces renal fibrosis in obstructive nephropathy in mice, by inhibiting renal interstitial matrix expression and myofibroblast activation, decreasing renal proinflammatory cytokine RANTES and TNF-α level.Trandolapril (0.3 mg/kg/day; p.o.; 4 weeks) improves arterial mechanics in rats, prevents arterial hypertrophy, collagen and cellular fibronectin accumulation.randolapril (0.3 mg/kg/day; p.o.; 4 months) exhibits a chronic anti-hypertension effects in rats, results in blood pressure decreasing.Trandolapril (0.25 mg/kg; p.o.; twice a day; 4 months) inhibits Atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit.Animal Model:UUD (unilateral ureteral obstruction) model in Male CD-1 mice (18-22 g)
Dosage:3 mg/kg
Administration:Oral gavage; daily, for 7 days
Result:Resulted in renal interstitial matrix expression (including fibronectin, type I, and type III collagen) decreasing, and inhibited myofibroblast activation by surprising a-smooth muscle actin (a-SMA) expression, decreased the RANTES (regulated on activation, normal T cell expressed and secreted) and TNF-α level.
Animal Model:SHR model (spontaneously hypertensive rats, 4-week-old)
Dosage:0.3 mg/kg
Administration:Oral gavage; daily for 4 weeks
Result:Reduced collagen content in the aortic media and increased ariterial distensibility up to about 80%.
Animal Model:Watanabe heritable hyperlipidemic rabbit (3 months old)
Dosage:0.25 mg/kg
Administration:Oral gavage; twice a day; 9 months
Result:Decreased in atherosclerotic involvement of the intimal surface, and also decreased cholesterol content in descending thoracic aorta.
体外研究：
Trandolapril (0.02 mM, 1 mM; 3 d) inhibits cell growth and induces cell apoptosis, increases the percentage of apoptotic cells in K562 cell line.
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