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编 号:F492663
分子式:C28H36N4O7
分子量:540.61
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生物活性:
Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities.

体内研究:
Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F1 (CD2F1) mice weighing 19-24 g. The LD50 is 7.3 mg/kg with safracin B in normal CD2F1 mice by ip administration.
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