产品
编 号：F491702
分子式：C30H31FN4O3
分子量：514.59
分子式：C30H31FN4O3
分子量：514.59
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 874374-25-1
产品详情
生物活性：
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
体内研究：
Ned 19 (i.p.; 5?mg/Kg/every second day; 4 week) impaires severely tumor growth. Animal Model:Adult male C57BL/6 mice
Dosage:5?mg/Kg
Administration:I.p.; every second day; 4 week
Result:Impaired severely tumor growth.
体外研究：
Ned 19 (25-100 μM; 24-72?hours) reduces cell proliferation.Ned 19 (25-100 μM; 24-72?hours) reduces markedly the cell number.Ned 19 (25-100 μM; 24-72?hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis. Ned 19 (25-100 μM; 24-72?hours) induces cell apoptosis a time-dependent manner. Ned 19 (25-100 μM; 24-72?hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior.
Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
体内研究：
Ned 19 (i.p.; 5?mg/Kg/every second day; 4 week) impaires severely tumor growth. Animal Model:Adult male C57BL/6 mice
Dosage:5?mg/Kg
Administration:I.p.; every second day; 4 week
Result:Impaired severely tumor growth.
体外研究：
Ned 19 (25-100 μM; 24-72?hours) reduces cell proliferation.Ned 19 (25-100 μM; 24-72?hours) reduces markedly the cell number.Ned 19 (25-100 μM; 24-72?hours) reduces the S phase percentage and increases of the G0/G1 phase percentage evaluated by cell cycle analysis. Ned 19 (25-100 μM; 24-72?hours) induces cell apoptosis a time-dependent manner. Ned 19 (25-100 μM; 24-72?hours) reduces expression of N-cadherin and increases expression of E-cadherin, affecting the cell migratory behavior.
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