产品
编 号：F491291
分子式：C52H74Cl2O18
分子量：1058.04
分子式：C52H74Cl2O18
分子量：1058.04
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
160
In-stock
10mg
240
In-stock
25mg
360
In-stock
50mg
520
In-stock
100mg
784
In-stock
结构图
CAS No: 873857-62-6
产品详情
生物活性：
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12?μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research.
体内研究：
Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis.Animal Model:Male Golden Syrian hamsters (80-100 g, Hamster model for pseudomembranous colitis)
Dosage:0.2, 1, and 5 mg/kg
Administration:Orally, once a day for 5 days, beginning 8 h after infection
Result:Completely prevented the lethality of the animals. Completely prevented the development of antibiotic-induced C. difficile colitis in hamsters at doses as low as 0.2 mg/kg.
体外研究：
Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024?μg/mL).
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12?μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research.
体内研究：
Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis.Animal Model:Male Golden Syrian hamsters (80-100 g, Hamster model for pseudomembranous colitis)
Dosage:0.2, 1, and 5 mg/kg
Administration:Orally, once a day for 5 days, beginning 8 h after infection
Result:Completely prevented the lethality of the animals. Completely prevented the development of antibiotic-induced C. difficile colitis in hamsters at doses as low as 0.2 mg/kg.
体外研究：
Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024?μg/mL).
产品资料
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