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编 号：F490923
分子式：C22H32O5
分子量：376.49
分子式：C22H32O5
分子量：376.49
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CAS No: 872993-05-0
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生物活性：
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages.
体内研究：
Resolvin D1 (RvD1) (100-1000 ng；腹腔注射；第 10 天每天) 改善关节炎小鼠的 RA (类风湿性关节炎) 临床终点。Animal Model:18-20?g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))
Dosage:100, 500, and 1000?ng (or 1000 ng, daily on days 4-10)
Administration:i.p. injection; daily on days 10
Result:Exhibit a reduced arthritic score.
体外研究：
Resolvin D1 (RvD1) (1-100 nM；15 分钟) 在原代人巨噬细胞中诱导剂量依赖性短期功能变化。RvD1 触发细胞内 Ca2+ 释放，阻断趋化性迁移，并刺激微生物颗粒的吞噬作用，在 10 nM时效率最高。Resolvin D1 (0-500 nM；72 小时) 在 RAW264.7 巨噬细胞中显示出不同浓度的 RvD1 对 LPS 诱导的 TRAP 和组织蛋白酶 K 表达的强烈抑制作用。
Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages.
体内研究：
Resolvin D1 (RvD1) (100-1000 ng；腹腔注射；第 10 天每天) 改善关节炎小鼠的 RA (类风湿性关节炎) 临床终点。Animal Model:18-20?g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))
Dosage:100, 500, and 1000?ng (or 1000 ng, daily on days 4-10)
Administration:i.p. injection; daily on days 10
Result:Exhibit a reduced arthritic score.
体外研究：
Resolvin D1 (RvD1) (1-100 nM；15 分钟) 在原代人巨噬细胞中诱导剂量依赖性短期功能变化。RvD1 触发细胞内 Ca2+ 释放，阻断趋化性迁移，并刺激微生物颗粒的吞噬作用，在 10 nM时效率最高。Resolvin D1 (0-500 nM；72 小时) 在 RAW264.7 巨噬细胞中显示出不同浓度的 RvD1 对 LPS 诱导的 TRAP 和组织蛋白酶 K 表达的强烈抑制作用。
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