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编 号：F490266
分子式：C24H26N4O5
分子量：450.49
分子式：C24H26N4O5
分子量：450.49
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CAS No: 871656-65-4
产品详情
生物活性：
AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).
体内研究：
AZD1092 (oral; 1, 3, 10 mg/kg) 呈剂量依赖性降低 Zucker 大鼠血糖波动，具有降糖作用。Animal Model:Female Zucker rats
Dosage:1, 3, 10 mg/kg
Administration:Oral
Result:Exhibited dose dependent reduction of glucose excursion in oral glucose tolerance tests in high fat fed female Zucker rats and glucose lowering efficacy in free feeding glucose profiles in male Zucker rats.
体外研究：
AZD1092 对葡萄糖激酶具有活性，EC50 值为 0.03 μM。
AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).
体内研究：
AZD1092 (oral; 1, 3, 10 mg/kg) 呈剂量依赖性降低 Zucker 大鼠血糖波动，具有降糖作用。Animal Model:Female Zucker rats
Dosage:1, 3, 10 mg/kg
Administration:Oral
Result:Exhibited dose dependent reduction of glucose excursion in oral glucose tolerance tests in high fat fed female Zucker rats and glucose lowering efficacy in free feeding glucose profiles in male Zucker rats.
体外研究：
AZD1092 对葡萄糖激酶具有活性，EC50 值为 0.03 μM。
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