产品
编 号：F489740
分子式：C18H18N2O
分子量：278.35
分子式：C18H18N2O
分子量：278.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 870888-46-3
产品详情
生物活性：
AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM).
体内研究：
AC-262536 (3, 10, 30 mg/kg) reverses the luteinizing hormone (LH) spike in castrated rats.Animal Model:Male Sprague-Dawley rats (200-225 g)
Dosage:3, 10 and 30 mg/kg
Administration:Administered subcutaneously; once daily for 14 consecutive days
Result:Significantly decreased LH levels by about 40% at the 3 mg/kg dose.The ED50 was determined to be 2.8 mg/kg.At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively.
体外研究：
AC-262536 dose-dependently inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP. The effects are significant with 100 nM AC-262536 (%inhibition 47.2±12.2), and reaches a plateau with 1 μM treatment (%inhibition 50.7±7.6). Thus, AC-262536 can act as a functional antagonist in prostate cells.
AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM).
体内研究：
AC-262536 (3, 10, 30 mg/kg) reverses the luteinizing hormone (LH) spike in castrated rats.Animal Model:Male Sprague-Dawley rats (200-225 g)
Dosage:3, 10 and 30 mg/kg
Administration:Administered subcutaneously; once daily for 14 consecutive days
Result:Significantly decreased LH levels by about 40% at the 3 mg/kg dose.The ED50 was determined to be 2.8 mg/kg.At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively.
体外研究：
AC-262536 dose-dependently inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP. The effects are significant with 100 nM AC-262536 (%inhibition 47.2±12.2), and reaches a plateau with 1 μM treatment (%inhibition 50.7±7.6). Thus, AC-262536 can act as a functional antagonist in prostate cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备