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编 号:F487857
分子式:C28H41N5O6S
分子量:575.72
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells.

体内研究:
ADAM10 和 ADAM17 的药理学抑制可改善脊髓损伤 (SCI) 后的功能恢复。Animal Model:C57BL/6 mice
Dosage:100 ?μg/kg
Administration:I.p. injected; every day for one week starting 4?h post-surgery
Result:Showed significantly improved functional recovery compared to the control group.

体外研究:
用 GW280264X 或 ADAM10/17 共同敲低处理后,GS-7 细胞的增殖显著减少。
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