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编 号:F487598
分子式:C16H14O4
分子量:270.28
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生物活性:
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma.

体外研究:
Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines.Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells.Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells.Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with Ki values of 988.9 nM and 1.76 μM respectively.
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