产品
编 号：F486681
分子式：C36H61N5O7S
分子量：707.96
分子式：C36H61N5O7S
分子量：707.96
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
询价
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10mg
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50mg
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结构图
CAS No: 865466-24-6
产品详情
生物活性：
Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM.
体内研究：
Pharmacokinetic Analysis Narlaprevir (SCH 900518) exhibits middle oral bioavailability (rat 46%, dog 29%, monkey 46 %) following oral administration (rat 10 mg/kg, dog 3 mg/kg, monkey 3 mg/kg ).Narlaprevir (SCH 900518) exhibits moderate half-lives (rat 4.8 and dog 2 h) following intravenous administration (rat 4 and dog 1 mg/kg).Animal Model:rats, dogs, monkeys
Dosage:Rat PO/IV 10/4 mg/kg; dog PO/IV 3/1 mg/kg; monkey PO 3 mg/kg
Administration:Intravenous (i.v.) or oral gavage
Result:T1/2s of 4.8 and 2 h for rats and dogs, respectively.
体外研究：
Narlaprevir (SCH 900518) potently inhibits ketoamide with a Ki value of 7 nM.Narlaprevir (SCH 900518) potently inhibits replicon RNA with an EC90 value of 40 nM.
Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM.
体内研究：
Pharmacokinetic Analysis Narlaprevir (SCH 900518) exhibits middle oral bioavailability (rat 46%, dog 29%, monkey 46 %) following oral administration (rat 10 mg/kg, dog 3 mg/kg, monkey 3 mg/kg ).Narlaprevir (SCH 900518) exhibits moderate half-lives (rat 4.8 and dog 2 h) following intravenous administration (rat 4 and dog 1 mg/kg).Animal Model:rats, dogs, monkeys
Dosage:Rat PO/IV 10/4 mg/kg; dog PO/IV 3/1 mg/kg; monkey PO 3 mg/kg
Administration:Intravenous (i.v.) or oral gavage
Result:T1/2s of 4.8 and 2 h for rats and dogs, respectively.
体外研究：
Narlaprevir (SCH 900518) potently inhibits ketoamide with a Ki value of 7 nM.Narlaprevir (SCH 900518) potently inhibits replicon RNA with an EC90 value of 40 nM.
产品资料
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