产品
编 号：F486646
分子式：C22H24N2O5
分子量：396.44
分子式：C22H24N2O5
分子量：396.44
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 86541-78-8
产品详情
生物活性：
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.
体内研究：
Benazeprilat (10 mg/kg, intravenous injection) and amlodipine (0.5 mg/kg, intravenous injection) in combination produce great hypotensive effect.Benazepril (0.7 mg/kg, oral) markedly influences the dynamics of systemic RAAS peptides, resulting in a substantial decrease in AII and ALD while increasing PRA and AI.Animal Model:Male SHR (14-16 weeks of age, 250-350 g).
Dosage:10 mg/kg
Administration:I.V; once a day for 2 days.
Result:Produced hypotensive effect.
Animal Model:Beagle dogs (12.0-19.5 kg).
Dosage:0.7 mg/kg
Administration:P.O, once a day for 5 days.
Result:Effected systemic RAAS peptides.
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage.
体内研究：
Benazeprilat (10 mg/kg, intravenous injection) and amlodipine (0.5 mg/kg, intravenous injection) in combination produce great hypotensive effect.Benazepril (0.7 mg/kg, oral) markedly influences the dynamics of systemic RAAS peptides, resulting in a substantial decrease in AII and ALD while increasing PRA and AI.Animal Model:Male SHR (14-16 weeks of age, 250-350 g).
Dosage:10 mg/kg
Administration:I.V; once a day for 2 days.
Result:Produced hypotensive effect.
Animal Model:Beagle dogs (12.0-19.5 kg).
Dosage:0.7 mg/kg
Administration:P.O, once a day for 5 days.
Result:Effected systemic RAAS peptides.
产品资料
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