产品
编 号：F485916
分子式：C17H21ClFN3O4
分子量：385.82
分子式：C17H21ClFN3O4
分子量：385.82
产品类型
规格
价格
是否有货
500mg
280
In-stock
1g
320
In-stock
5g
640
In-stock
结构图
CAS No: 86393-32-0
产品详情
生物活性：
Ciprofloxacin (Bay-09867) hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin hydrochloride monohydrate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin hydrochloride monohydrate has anti-proliferative activity and induces apoptosis. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
体内研究：
Ciprofloxacin (Bay-09867) hydrochloride monohydrate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) hydrochloride monohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall.Ciprofloxacin (Bay-09867) hydrochloride monohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall.Animal Model:BALB/c mice
Dosage:30 mg/kg
Administration:Intraperitoneal injection; for 24 hours
Result:Reduced the lung bacterial load in murine model of pneumonic plague.
Animal Model:C57BL/6J mice
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.
Animal Model:C57BL/6J mice
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
体外研究：
Ciprofloxacin (Bay-09867) hydrochloride monohydrate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) hydrochloride monohydrate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively.
Ciprofloxacin (Bay-09867) hydrochloride monohydrate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin hydrochloride monohydrate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin hydrochloride monohydrate has anti-proliferative activity and induces apoptosis. Ciprofloxacin hydrochloride monohydrate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
体内研究：
Ciprofloxacin (Bay-09867) hydrochloride monohydrate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague.Ciprofloxacin (Bay-09867) hydrochloride monohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall.Ciprofloxacin (Bay-09867) hydrochloride monohydrate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall.Animal Model:BALB/c mice
Dosage:30 mg/kg
Administration:Intraperitoneal injection; for 24 hours
Result:Reduced the lung bacterial load in murine model of pneumonic plague.
Animal Model:C57BL/6J mice
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.
Animal Model:C57BL/6J mice
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
体外研究：
Ciprofloxacin (Bay-09867) hydrochloride monohydrate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase.Ciprofloxacin (Bay-09867) hydrochloride monohydrate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively.
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