产品
编 号:F485910
分子式:C23H20O3
分子量:344.4
产品类型
结构图
CAS No: 863918-78-9
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产品详情
生物活性:
Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity.
体内研究:
Methoxy-X04 (5-10 mg/kg,腹腔注射,一次) 可在 30 至 60 分钟内区分 PS1/APP 小鼠的单个斑块。