产品
编 号：F485522
分子式：C30H24N4O8
分子量：568.53
分子式：C30H24N4O8
分子量：568.53
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
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50mg
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询价
结构图
CAS No: 863031-21-4
产品详情
生物活性：
Azilsartan medoxomil (TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
体内研究：
Azilsartan medoxomil (0.03-1 mg/kg，口服) 抑制正常血压大鼠中血管紧张素 II 诱导的升压反应。Azilsartan medoxomil (花生酱中 0.1-10 mg/kg，每日一次) 抑制 I 型纤溶酶原激活剂抑制剂 (PAI-1) 蛋白的血管壁表达，并可能促进 ApoE 敲除小鼠 (高脂饮食) (VSMC 中 PAI-1 过度表达) 动脉粥样硬化斑块的稳定 。Azilsartan medoxomil (0.03-10 mg/kg，口服灌胃，每天一次) 可减少大鼠心肌梗死面积。Animal Model:Rats
Dosage:0.03-10 mg/kg
Administration:oral gavage, once a day for 4 days
Result:Reduced myocardial infarct size.Increased calcium-dependent nitric oxide synthase activity.Increased Akt, ERK 1/2 and eNOS phosphorylation and inhibited BAX activation.
Azilsartan medoxomil (TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
体内研究：
Azilsartan medoxomil (0.03-1 mg/kg，口服) 抑制正常血压大鼠中血管紧张素 II 诱导的升压反应。Azilsartan medoxomil (花生酱中 0.1-10 mg/kg，每日一次) 抑制 I 型纤溶酶原激活剂抑制剂 (PAI-1) 蛋白的血管壁表达，并可能促进 ApoE 敲除小鼠 (高脂饮食) (VSMC 中 PAI-1 过度表达) 动脉粥样硬化斑块的稳定 。Azilsartan medoxomil (0.03-10 mg/kg，口服灌胃，每天一次) 可减少大鼠心肌梗死面积。Animal Model:Rats
Dosage:0.03-10 mg/kg
Administration:oral gavage, once a day for 4 days
Result:Reduced myocardial infarct size.Increased calcium-dependent nitric oxide synthase activity.Increased Akt, ERK 1/2 and eNOS phosphorylation and inhibited BAX activation.
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