产品
编 号：F485469
分子式：C25H25NO3
分子量：387.47
分子式：C25H25NO3
分子量：387.47
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CAS No: 862891-27-8
产品详情
生物活性：
CAY10583 is a potent and selective full Leukotriene B4 receptor type 2 (BLT2) agonist. CAY10583 directly promotes keratinocyte migration in vitro and accelerates wound closure in vivo. CAY10583 is a promising pharmaceutical agent for diabetic wounds.
体内研究：
CAY10583 (administered topically to full-thickness wounds; 10 μM; 14 days)significantly results in a greater wound closure than the control group. The difference in wound closure between the CAY-treated group and the control group is pronounced over time until day 10. And the difference is approximately 6% at day 4 and reaches almost 20% at day 8. Notably, 100% closure was observed in the CAY-treated group at day 14.Animal Model:Lewis rats (6-9 weeks of age, 180-220 g)
Dosage:10 μM; 14 days
Administration:Administered topically to full-thickness wounds; 10 μM; 14 days
Result:Accelerated in vivo wound healing by topical application.
体外研究：
CAY10583 (1 nM-1μM; 24 hours) promotes wound closure via keratinocyte migration. And CAY10583 has no significant effect of on keratinocyte proliferation.
CAY10583 is a potent and selective full Leukotriene B4 receptor type 2 (BLT2) agonist. CAY10583 directly promotes keratinocyte migration in vitro and accelerates wound closure in vivo. CAY10583 is a promising pharmaceutical agent for diabetic wounds.
体内研究：
CAY10583 (administered topically to full-thickness wounds; 10 μM; 14 days)significantly results in a greater wound closure than the control group. The difference in wound closure between the CAY-treated group and the control group is pronounced over time until day 10. And the difference is approximately 6% at day 4 and reaches almost 20% at day 8. Notably, 100% closure was observed in the CAY-treated group at day 14.Animal Model:Lewis rats (6-9 weeks of age, 180-220 g)
Dosage:10 μM; 14 days
Administration:Administered topically to full-thickness wounds; 10 μM; 14 days
Result:Accelerated in vivo wound healing by topical application.
体外研究：
CAY10583 (1 nM-1μM; 24 hours) promotes wound closure via keratinocyte migration. And CAY10583 has no significant effect of on keratinocyte proliferation.
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