产品
编 号：F484878
分子式：C21H25NO
分子量：307.43
分子式：C21H25NO
分子量：307.43
产品类型
规格
价格
是否有货
结构图
CAS No: 86-13-5
产品详情
生物活性：
Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.
体内研究：
Benztropine (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model.Animal Model:Balb/c mice bearing 4T1 breast tumors
Dosage:1.5 mg/kg
Administration:Injection; 3 weeks
Result:Reduced the tumor size and weight significantly without body weight changing.
体外研究：
Benztropine (0.1-10 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC50 value about 5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine reduces the size as well as the number of mammospheres significantly in a dose-dependent manne.Benztropine inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors.Benztropine induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced remyelination.
Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.
体内研究：
Benztropine (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model.Animal Model:Balb/c mice bearing 4T1 breast tumors
Dosage:1.5 mg/kg
Administration:Injection; 3 weeks
Result:Reduced the tumor size and weight significantly without body weight changing.
体外研究：
Benztropine (0.1-10 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC50 value about 5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine reduces the size as well as the number of mammospheres significantly in a dose-dependent manne.Benztropine inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors.Benztropine induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced remyelination.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备