产品
编 号：F483161
分子式：C18H24N4O4
分子量：360.41
分子式：C18H24N4O4
分子量：360.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 857652-30-3
产品详情
生物活性：
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders.
体内研究：
PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats.Animal Model:Diet-induced obese (DIO) rats
Dosage:100 mg/kg
Administration:P.o.; daily for 14 days
Result:The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss.
体外研究：
PSN632408 produces concentration-dependent increases in cAMP level with mean EC50 value of 1.9 uM.PSN632408 stimulates β cell replication in cultured mouse islets.
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders.
体内研究：
PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats.Animal Model:Diet-induced obese (DIO) rats
Dosage:100 mg/kg
Administration:P.o.; daily for 14 days
Result:The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss.
体外研究：
PSN632408 produces concentration-dependent increases in cAMP level with mean EC50 value of 1.9 uM.PSN632408 stimulates β cell replication in cultured mouse islets.
产品资料
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