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编 号:F057053
分子式:C22H24O9
分子量:432.42
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1mg
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5mg
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10mg
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生物活性:
3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma.

体内研究:
3, 5, 6, 7, 8, 3', 4'- Heptemthoxyflavone (HPT) 在小鼠皮肤乳头瘤由 NORI 发的体内两期癌变试验中,抑制 NOR1/TPA 诱导的肿瘤进展。3, 5, 6, 7, 8, 3', 4'- Heptemthoxyflavone (HMF) (50 mg/kg, 100 mg/kg; 口服; 每天 1 次共 15 天) 在皮质酮 (HY-B1618) 诱导的抑郁样小鼠模型中,还通过增强星形胶质细胞中 BDNF 的表达来发挥神经保护作用。

体外研究:
3,5,6,7,8,3',4'-Heptemthoxyflavone (HMF) (50-400 μg/mL; 24 h) 在 3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone 相关抗体:
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