产品
编 号：F057018
分子式：C24H38O4
分子量：390.56
分子式：C24H38O4
分子量：390.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
480
In-stock
结构图
CAS No: 117-81-7
产品详情
生物活性：
DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity.
体内研究：
DEHP (0-500 mg/kg, 口服, 每日一次, 8 周) 会损害雌性 C3H/N 小鼠的生育能力。Animal Model:Female C3H/N mice
Dosage:0-500 mg/kg
Administration:p.o., daily, 8 weeks
Result:Increased the body weight and visceral fat tissue.Increased the expression of PPARα and PPARγ mRNA at the dose of 500 mg/kg.Decreased mRNA expression of PPARα transcripts/106 18S molecules at the dose of 500 mg/kg.Reduced the level of adiponectin mRNA.Increased the mRNA concentration of FABP4 at the dose of 0.05 mg/kg.
体外研究：
DEHP (0-160 μM, 48 h) 显著抑制了小鼠 GC-1 spg 细胞的细胞活力。DEHP (0-160 μM, 48 h) 通过氧化应激诱导小鼠 GC-1 spg 细胞自噬和凋亡。
DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity.
体内研究：
DEHP (0-500 mg/kg, 口服, 每日一次, 8 周) 会损害雌性 C3H/N 小鼠的生育能力。Animal Model:Female C3H/N mice
Dosage:0-500 mg/kg
Administration:p.o., daily, 8 weeks
Result:Increased the body weight and visceral fat tissue.Increased the expression of PPARα and PPARγ mRNA at the dose of 500 mg/kg.Decreased mRNA expression of PPARα transcripts/106 18S molecules at the dose of 500 mg/kg.Reduced the level of adiponectin mRNA.Increased the mRNA concentration of FABP4 at the dose of 0.05 mg/kg.
体外研究：
DEHP (0-160 μM, 48 h) 显著抑制了小鼠 GC-1 spg 细胞的细胞活力。DEHP (0-160 μM, 48 h) 通过氧化应激诱导小鼠 GC-1 spg 细胞自噬和凋亡。
产品资料
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