产品
编 号：F482019
分子式：C15H22N4O6
分子量：354.36
分子式：C15H22N4O6
分子量：354.36
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 85541-78-2
产品详情
生物活性：
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.
体内研究：
(Glu2)-TRH (1-100 μmol/kg; 静脉注射) 剂量依赖性地减弱 TRH 诱导的兴奋作用。(Glu2)-TRH (10 μmol/kg; 静脉注射) 在戊巴比妥 (60 mg/kg; 腹腔) 前 10 分钟给药，与载体处理组相比，睡眠时间减少了大约 20%。Animal Model:Male Swiss-Webster mice (30 g)
Dosage:1, 2, 5, 10, 15, 25, 50, 100 μmol/kg
Administration:IV; 10 min before Pentobarbital (60 mg/kg, i.p.)
Result:Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.
体内研究：
(Glu2)-TRH (1-100 μmol/kg; 静脉注射) 剂量依赖性地减弱 TRH 诱导的兴奋作用。(Glu2)-TRH (10 μmol/kg; 静脉注射) 在戊巴比妥 (60 mg/kg; 腹腔) 前 10 分钟给药，与载体处理组相比，睡眠时间减少了大约 20%。Animal Model:Male Swiss-Webster mice (30 g)
Dosage:1, 2, 5, 10, 15, 25, 50, 100 μmol/kg
Administration:IV; 10 min before Pentobarbital (60 mg/kg, i.p.)
Result:Dose-dependently attenuated TRH-induced (10 μmol/kg; iv) analeptic action.
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