产品
编 号:F481142
分子式:C18H24N2O5S
分子量:380.46
产品类型
结构图
CAS No: 85320-68-9
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产品详情
生物活性:
Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR).
体内研究:
Amosulalol (3-30 mg/kg; 口服; 单剂量) 降低高血压大鼠的急性收缩压。Amosulalol (50 mg/kg; 口服; 每天 2 次, 共 12 周) 产生不耐受的降压作用,还降低高血压大鼠模型中心率和血浆肾素活性 (PRA) 增加。