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编 号：F479840
分子式：C23H29Cl2N3O3
分子量：466.4
分子式：C23H29Cl2N3O3
分子量：466.4
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CAS No: 851220-85-4
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生物活性：
Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19.
体内研究：
Aripiprazole monohydrate (0-3 mg/kg, IP, daily) shows some anxiolytic properties.Animal Model:WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)
Dosage:0, 0.3, 1, 3 mg/kg
Administration:IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments
Result:Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
体外研究：
Aripiprazole monohydrate potently activates D2 receptor-mediated inhibition of cAMP accumulation.Aripiprazole monohydrate shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.
Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19.
体内研究：
Aripiprazole monohydrate (0-3 mg/kg, IP, daily) shows some anxiolytic properties.Animal Model:WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam)
Dosage:0, 0.3, 1, 3 mg/kg
Administration:IP, 1 mL/kg, every day at 5 p.m. until the end of the experiments
Result:Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
体外研究：
Aripiprazole monohydrate potently activates D2 receptor-mediated inhibition of cAMP accumulation.Aripiprazole monohydrate shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.
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