产品
编 号：F478498
产品类型
规格
价格
是否有货
100mg
400
In-stock
250mg
800
In-stock
500mg
1360
In-stock
结构图
CAS No: 84929-27-1
产品详情
生物活性：
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells.
体内研究：
Grape seed extract (200 mg/kg; i.g.; 5 days/wk; for 8 weeks) inhibits HT29 colon carcinoma tumor xenograft growth in athymic nude mice.Grape seed extract inhibits cell proliferation but increases apoptotic cell death in tumors.Grape seed extract enhances Cip1/p21protein levels and poly(ADP-ribose) poly-merase cleavage in tumors.Animal Model:Athymic male nu/nu mice, with human colon carcinoma HT29 tumor xenograft
Dosage:200 mg/kg
Administration:Oral gavage, 5 days/wk, for 8 weeks
Result:Showed time-dependent inhibition of tumor growth.
体外研究：
Grape seed extract (25-100 μg/mL; 12-48 hours) inhibits growth and induces death in human colorectal cancer cells.Grape seed extract (25-100 μg/mL; 12-24 hours) modulates the protein levels of cell cycle regulatory molecules in HT29 and LoVo cells.Grape seed extract (25-100 μg/mL; 24 hours) causes apoptotic cell death of human colorectal cancer cells.
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells.
体内研究：
Grape seed extract (200 mg/kg; i.g.; 5 days/wk; for 8 weeks) inhibits HT29 colon carcinoma tumor xenograft growth in athymic nude mice.Grape seed extract inhibits cell proliferation but increases apoptotic cell death in tumors.Grape seed extract enhances Cip1/p21protein levels and poly(ADP-ribose) poly-merase cleavage in tumors.Animal Model:Athymic male nu/nu mice, with human colon carcinoma HT29 tumor xenograft
Dosage:200 mg/kg
Administration:Oral gavage, 5 days/wk, for 8 weeks
Result:Showed time-dependent inhibition of tumor growth.
体外研究：
Grape seed extract (25-100 μg/mL; 12-48 hours) inhibits growth and induces death in human colorectal cancer cells.Grape seed extract (25-100 μg/mL; 12-24 hours) modulates the protein levels of cell cycle regulatory molecules in HT29 and LoVo cells.Grape seed extract (25-100 μg/mL; 24 hours) causes apoptotic cell death of human colorectal cancer cells.
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