产品
编 号：F478455
分子式：C20H24N10O13P2
分子量：674.41
分子式：C20H24N10O13P2
分子量：674.41
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 849214-04-6
产品详情
生物活性：
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
体内研究：
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.Animal Model:Female C57BL/6 (H-2b) mice 6–8 weeks old
Dosage:5 μg
Administration:Nostril mucosal adjuvant
Result:Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
体外研究：
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.cGAMP directly activates murine and human dendritic cells in vitro.On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
体内研究：
cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.Animal Model:Female C57BL/6 (H-2b) mice 6–8 weeks old
Dosage:5 μg
Administration:Nostril mucosal adjuvant
Result:Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
体外研究：
cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.cGAMP directly activates murine and human dendritic cells in vitro.On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
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