产品
编 号：F478280
分子式：C42H52N6O9S
分子量：816.96
分子式：C42H52N6O9S
分子量：816.96
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规格
价格
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CAS No: 849022-32-8
产品详情
生物活性：
BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity.
体内研究：
BI-1230 (intravenous?injection; 2 mg/kg) shows good PK activity in rat: CL: 15 ml/min/kg, Mean residence time after iv dose: 2.3hours, Vss: 2.05 L/kg.BI-1230 (oral administation; 5 mg/kg) shows good PK activity in rat: T1/2: 2.1 hours; Tmax: 1.8 nM; Cmax: 405 nM; AUC0-inf: 2550 nM*h; F: 42%.
体外研究：
BI-1230 (60 min incubation) exhibits an IC50 value of 6.7 nM in a Enzymatic assay.BI-1230 (72 hours) shows EC50 values of 4.6 nM and BI-1230 相关抗体:
BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity.
体内研究：
BI-1230 (intravenous?injection; 2 mg/kg) shows good PK activity in rat: CL: 15 ml/min/kg, Mean residence time after iv dose: 2.3hours, Vss: 2.05 L/kg.BI-1230 (oral administation; 5 mg/kg) shows good PK activity in rat: T1/2: 2.1 hours; Tmax: 1.8 nM; Cmax: 405 nM; AUC0-inf: 2550 nM*h; F: 42%.
体外研究：
BI-1230 (60 min incubation) exhibits an IC50 value of 6.7 nM in a Enzymatic assay.BI-1230 (72 hours) shows EC50 values of 4.6 nM and BI-1230 相关抗体:
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