产品
编 号：F478087
分子式：C24H28N4O4S
分子量：468.57
分子式：C24H28N4O4S
分子量：468.57
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CAS No: 848647-56-3
产品详情
生物活性：
J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats.
体内研究：
J-2156 (1-10?mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats.Animal Model:Breast cancer-induced bone pain (BCIBP)-rats
Dosage:1, 3, 10?mg/kg
Administration:IP; for 3 hours
Result:Had anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats.
体外研究：
J-2156 binds with nanomolar affinity to the human somatostatin receptor subtype 4 (h sst4: Ki=1.2 nM) and is over 400-fold subtype-selective against the other somatostatin receptors (h sst1: Ki=1.2 nM; h sst2: Ki>5000 nM; h sst3: Ki=1400 nM; h sst5: Ki=540 nM) in Chinese hamster ovary (CHO) cells.
J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats.
体内研究：
J-2156 (1-10?mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats.Animal Model:Breast cancer-induced bone pain (BCIBP)-rats
Dosage:1, 3, 10?mg/kg
Administration:IP; for 3 hours
Result:Had anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats.
体外研究：
J-2156 binds with nanomolar affinity to the human somatostatin receptor subtype 4 (h sst4: Ki=1.2 nM) and is over 400-fold subtype-selective against the other somatostatin receptors (h sst1: Ki=1.2 nM; h sst2: Ki>5000 nM; h sst3: Ki=1400 nM; h sst5: Ki=540 nM) in Chinese hamster ovary (CHO) cells.
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