产品
编 号：F477721
分子式：C15H14O3
分子量：242.27
分子式：C15H14O3
分子量：242.27
产品类型
规格
价格
是否有货
5mg
250
In-stock
10mg
400
In-stock
50mg
800
In-stock
100mg
1200
In-stock
结构图
CAS No: 84-79-7
产品详情
生物活性：
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity.
体内研究：
Lapachol (3, 10 mg/kg；口服灌胃；每天一次，持续 4 周) 可降低 CIA 小鼠模型中实验性关节炎的严重程度。 Lapachol (10 mg/kg；口服灌胃；每天一次，持续 9 天) 在患有抗原诱导性关节炎 (AIA) 的雄性 C57BL/6 小鼠中，显示出膝关节白细胞浸润显着减少。 Animal Model:Male DBA1/J mice (10-12 weeks old) with collagen-induced arthritis (CIA) models
Dosage:3 mg/kg and 10 mg/kg
Administration:Orally; once a day for 4 weeks
Result:Markedly attenuated the severity of arthritis in CIA mice at both doses. Markedly reduced all histopathological features of arthritis severity.
体外研究：
Lapachol (10-100 μM；4 天) 通过抑制嘧啶生物合成来抑制淋巴细胞增殖。
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity.
体内研究：
Lapachol (3, 10 mg/kg；口服灌胃；每天一次，持续 4 周) 可降低 CIA 小鼠模型中实验性关节炎的严重程度。 Lapachol (10 mg/kg；口服灌胃；每天一次，持续 9 天) 在患有抗原诱导性关节炎 (AIA) 的雄性 C57BL/6 小鼠中，显示出膝关节白细胞浸润显着减少。 Animal Model:Male DBA1/J mice (10-12 weeks old) with collagen-induced arthritis (CIA) models
Dosage:3 mg/kg and 10 mg/kg
Administration:Orally; once a day for 4 weeks
Result:Markedly attenuated the severity of arthritis in CIA mice at both doses. Markedly reduced all histopathological features of arthritis severity.
体外研究：
Lapachol (10-100 μM；4 天) 通过抑制嘧啶生物合成来抑制淋巴细胞增殖。
产品资料
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