产品
编 号：F477409
分子式：C26H24FN3O3
分子量：445.49
分子式：C26H24FN3O3
分子量：445.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 847553-89-3
产品详情
生物活性：
SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
体内研究：
SHA 68 (ip；5 和 50 mg/kg) 减少 NPS 诱导的水平活动和垂直饲养和攀爬。 SHA 68 (iv；1 mg/kg) 的 T1/2 为 0.74 小时，CL 为 4.29 mL/min/kg，Vss 为 2.53 L/kg。 SHA 68 (ip；2.5 mg/kg) 的 T1/2 为 0.43 小时，CL 为 4.56 mL/min/kg。Animal Model:Male C57BL/6 mice age 8-12 weeks
Dosage:5 and 50 mg/kg
Administration:i.p.
Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.
Animal Model:Male C57BL/6 mice age 8-12 weeks
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:i.p.
Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
体内研究：
SHA 68 (ip；5 和 50 mg/kg) 减少 NPS 诱导的水平活动和垂直饲养和攀爬。 SHA 68 (iv；1 mg/kg) 的 T1/2 为 0.74 小时，CL 为 4.29 mL/min/kg，Vss 为 2.53 L/kg。 SHA 68 (ip；2.5 mg/kg) 的 T1/2 为 0.43 小时，CL 为 4.56 mL/min/kg。Animal Model:Male C57BL/6 mice age 8-12 weeks
Dosage:5 and 50 mg/kg
Administration:i.p.
Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.
Animal Model:Male C57BL/6 mice age 8-12 weeks
Dosage:1 mg/kg (Pharmacokinetic Analysis)
Administration:i.p.
Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
产品资料
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