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编 号：F477276
分子式：C32H35N7O4
分子量：581.66
分子式：C32H35N7O4
分子量：581.66
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CAS No: 847375-16-0
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生物活性：
WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder.
体内研究：
WAY-267464 (i.p., 100 mg/kg) has antagonism of the memory-enhancing effects of AVP (0.005 mg/kg) on social recognition at a retention interval of 120 min.WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressin Vasopressin (HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min.WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval.Animal Model:Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)
Dosage:1, 10, 30, and 100 mg/kg
Administration:Intraperitoneal; 1, 10, 30, and 100 mg/kg
Result:Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats.Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.
WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder.
体内研究：
WAY-267464 (i.p., 100 mg/kg) has antagonism of the memory-enhancing effects of AVP (0.005 mg/kg) on social recognition at a retention interval of 120 min.WAY-267464 (i.p., 10 and 30 mg/kg) has the antagonist effects on the arginine vasopressin Vasopressin (HY-P0049) (AVP)-induced (0.005 mg/kg) facilitation of social recognition at a retention interval of 120 min.WAY-267464 (i.p., 30 and 100 mg/kg, given alone) impairs memory at a 30 min retention interval.Animal Model:Male Wistar Rats (adult: 9-10 weeks; juvenile: 3-4 weeks)
Dosage:1, 10, 30, and 100 mg/kg
Administration:Intraperitoneal; 1, 10, 30, and 100 mg/kg
Result:Completely prevented the AVP-induced preference for the novel over the familiar juvenile stimulus rats.Prevented the increase in preference for the novel over the familiar juvenile stimulus rat induced by AVP at 10 and 30 mg/kg, but not 1 mg/kg.
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