产品
编 号:F477167
分子式:C20H20O5
分子量:340.37
产品类型
结构图
CAS No: 84709-25-1
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产品详情
生物活性:
(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.
体外研究:
(?)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs.(?)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7.