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编 号:F477117
分子式:C47H74O17
分子量:911.08
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生物活性:
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection.

体外研究:
Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity to T. brucei rhodesiense, T. cruzi, L. donovani and P. falciparum with IC50 values of 9.5, 5.0, >30 and >20 μg/mL, respectively.Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells.
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