产品
编 号：F476911
分子式：C35H38Cl2N8O4
分子量：705.63
分子式：C35H38Cl2N8O4
分子量：705.63
产品类型
规格
价格
是否有货
100mg
412
In-stock
500mg
1584
In-stock
结构图
CAS No: 84625-61-6
产品详情
生物活性：
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
体内研究：
Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.Animal Model:Female outbred athymic nude mice (6-7-week-old) injected with Ptch+/? cells
Dosage:75 mg/kg, 100 mg/kg
Administration:Oral gavage; twice per day; for 18 days
Result:Suppressed Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.
体外研究：
Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM).Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro.
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
体内研究：
Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.Animal Model:Female outbred athymic nude mice (6-7-week-old) injected with Ptch+/? cells
Dosage:75 mg/kg, 100 mg/kg
Administration:Oral gavage; twice per day; for 18 days
Result:Suppressed Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.
体外研究：
Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM).Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro.
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