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编 号：F476451
分子式：C11H17F3N6O
分子量：306.29
分子式：C11H17F3N6O
分子量：306.29
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CAS No: 84545-30-2
产品详情
生物活性：
ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.
体内研究：
ICI 162846 (10 mg/kg，口服，每天两次持续 5 天) 降低了 CFLP 小鼠诱导的 CDU 模型中 CDU 的发生率，并抑制胃酸产生同时伴随组胺分泌增加。Animal Model:CFLP mice were irradiated to the lower mediastinum to induce CDU.
Dosage:10 mg/kg, twice daily for 5 days
Administration:Oral gavage (p.o.)
Result:Reduced the incidence of CDU. Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.
体内研究：
ICI 162846 (10 mg/kg，口服，每天两次持续 5 天) 降低了 CFLP 小鼠诱导的 CDU 模型中 CDU 的发生率，并抑制胃酸产生同时伴随组胺分泌增加。Animal Model:CFLP mice were irradiated to the lower mediastinum to induce CDU.
Dosage:10 mg/kg, twice daily for 5 days
Administration:Oral gavage (p.o.)
Result:Reduced the incidence of CDU. Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
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