产品
编 号：F475878
分子式：C19H20BrN3O3
分子量：418.28
分子式：C19H20BrN3O3
分子量：418.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 84379-13-5
产品详情
生物活性：
Bretazenil (Ro 16-6028) is a partial agonist at the gamma-aminobutyric acid A (GABAA) receptor-linked benzodiazepine site. Bretazenil is potent benzodiazepine examined, exhibiting an IC50 (concentration at which half-maximal inhibition of specific [35S]TBPS binding occurs) of 6.1 nM. Bretazenil shows an EC50 of 10 nM for recombinant α1β1γ2. Anticonvulsant effects.
体内研究：
Bretazenil (0.001-0.1 mg/kg intraperitoneally 10 min before metrazol; age 7, 12, 18, 25 and 90 days male and female albino rats)suppresses both types of metrazol-induced seizures, minimal (mMS, predominantly clonic with preserved righting ability) and major (MMS, generalized tonic-clonic) in a dose-dependent manner.
Bretazenil (Ro 16-6028) is a partial agonist at the gamma-aminobutyric acid A (GABAA) receptor-linked benzodiazepine site. Bretazenil is potent benzodiazepine examined, exhibiting an IC50 (concentration at which half-maximal inhibition of specific [35S]TBPS binding occurs) of 6.1 nM. Bretazenil shows an EC50 of 10 nM for recombinant α1β1γ2. Anticonvulsant effects.
体内研究：
Bretazenil (0.001-0.1 mg/kg intraperitoneally 10 min before metrazol; age 7, 12, 18, 25 and 90 days male and female albino rats)suppresses both types of metrazol-induced seizures, minimal (mMS, predominantly clonic with preserved righting ability) and major (MMS, generalized tonic-clonic) in a dose-dependent manner.
产品资料
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