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编 号：F474645
分子式：C214H348N60O65S
分子量：4833.48
分子式：C214H348N60O65S
分子量：4833.48
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CAS No: 83930-34-1
产品详情
生物活性：
[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin.
体内研究：
[Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys.Animal Model:Young adult male cynomolgus monkeys (4.0-6.9 kg)
Dosage:10 mL/h for 198 pg/min or 225 pg/min
Administration:Continuous infusions intravenous; collected every 60 min during 5-7 hr
Result:Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH).
体外研究：
[Tyr0] Corticotropin Releasing Factor, ovine has a strong binding effect with plasma protein.
[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin.
体内研究：
[Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys.Animal Model:Young adult male cynomolgus monkeys (4.0-6.9 kg)
Dosage:10 mL/h for 198 pg/min or 225 pg/min
Administration:Continuous infusions intravenous; collected every 60 min during 5-7 hr
Result:Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH).
体外研究：
[Tyr0] Corticotropin Releasing Factor, ovine has a strong binding effect with plasma protein.
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